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Conference Directory
Allosteric Modulator Congress
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Venue Name: n/a
Country: United States of America
City: San Diego
State: CA
Number of Attendees: Unknown
Webinar or Virtual Event: No
Keywords: Drug Discovery, Scientists, Pharmacologists
Start Date of Conference:: 11-11-2010
End Date of Conference: 11-12-2010
Description of Conference: This conference will highlight the entire drug discovery process as it pertains to the development of allosteric modulators and the challenges and recent successes associated with this exciting field.
Themes include:
*Screening for a specific target
*Hit to lead generation
*Lead optimization to clinical candidate
*Medicinal chemistry and Structure Activity Relationships (SARs) of allosteric modulators
*Therapeutic applications of Allosteric Modulators
Background
Allosteric modulators are an emerging class of orally available small molecule therapeutic agents that may be able to offer patients better outcomes than with traditional small molecule therapies. This potential stems from their ability to offer greater selectivity and better modulatory control at disease mediating receptors. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. The advent of functional assays as the screening method of choice is leading to an increase in the number of allosteric modulators identified.
Allosteric modulation is generating a great deal of excitement among researchers. Since orthosteric modulators need to compete with natural ligands, they require higher doses, raising safety issues. Allosteric modulators do not compete and may be effective at lower, safer doses.
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Allosteric Modulator Congress
